Nimesulide mechanism of action

Nimesulide is a prescription non-steroidal anti-inflammatory drug with a multifactorial mode of action, characterized by a fast onset of analgesic activity.It must be used un

der supervision by a doctor in accordance with the approved indications and in compliance with the recommendations included in the Summary of Product Characteristics.

In 1980 the original nimesulide molecule was in-licensed by Helsinn Healthcare, a pharmaceutical company based in Switzerland. In 1985 it was first launched in Italy by Helsinn's local licensees under the brand names Aulin and Mesulid.
Helsinn manufactures the original Nimesulide active ingredient and finished products in full compliance with the current Good Manufacturing Practice (cGMP) guidelines in its plants in Switzerland and Ireland.

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.
Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease
Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.
It has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide Gel

Nimesulide Gel Uses

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Original Nimesulide is commercially available as tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Gel (Nimesulide/Methyl Salicylate/Menthol/Capsaicin) is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains.

Dosage and Administration

Nimesulide Gel is apply to the affected area, rubbing in a thin layer of the gel 2 to 4 times every day. For best results, wash the application area beforehand to clean away any oil, grease, or bacteria, allowing the gel to absorb more easily.

Nimesulide is available in assortment of structures like as tablets and syrup for oral organization and gels for topical application.

The anti-inflammatory activity of topically applied Nimesulide gel demonstrations particularly on cyclo-oxygenase-2 which applies less gastrointestinal antagonistic impacts than different NSAIDs.

Nimesulide Painkiller Tablet

Nimesulide Painkiller Tablet

Nimesulide is used in giving relief from acute pain associated with rheumatoid arthritis, osteoarthritis and primary dysmenorrhoea in adolescents and adults.

The drug is also an effective antipyretic and used to treat headaches and flu. It is also used in treating inflammatory conditions in humans and pain caused by arthritis or severe injury.

Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Working of Nimesulide:

It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation

Nimesulide Dosage:

Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg drug interactions

Nimesulide is a leading NSAID’S srug with analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile.
Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea .
Nimesulide Tablet shows the result from pain within 15min from the drug intake
Nimesulide is available in the from of tablet, capsule and gel with the dosage of 100mg
Nimesulide is preffered for the shortest duration to minimize the risk of hepatotoxicity.
Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile. Since nimesulide may be prescribed for patients receiving concomitant medication, the propensity for drug interactions exists.
Major interactions involving interference with drug metabolism have not been described with Nimesulide.
A marginal decrease in plasma theophylline levels (without changes in respiratory function tests) has been described after addition of Nimesulide to chronic theophylline therapy. Nimesulide is available in the market with the dosage of 100mg.

Nimesulide Brands

The most powerfull painkiller NSAIDs tablet Nimesulide is been available since 1985 and authorised in worldwide over 50 countries.

It has superior gastrointestinal safety as compared to other NSAIDs.

It is available in various forms apart from tablets such as in the form of Gell, powder, and suppositories. It’s also available in several trademarks.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.
Nimulid is also obtaining in the form of gel.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide Advantages and Benifits

Nimesulide tablet was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide.

It is available in a variety of forms: tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel.

Nimesulide undergoes extensive biotransformation. Nimesulide has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

The usual dose is 100mg twice a day. The duration is recommended to use for 15 days.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.

The treatment also include from pains like primary dysmenorrhoea (Period pains).